New Spatial Gene Editing Method Unveiled: Perturb-FISH Advances Genetic Research
Key Points Perturb-FISH enhances gene circuitry analysis by preserving spatial relationships between cells. Developed at the Broad Institute, it combines CRISPR screening with spatial transcriptomics. The method revealed the effects of autism-related genes on brain cells and tumor-immune interactions. The technology can analyze 35 genes but aims to expand its capabilities further. Scientists have developed a cutting-edge technology called Perturb-FISH that enhances the ability to study gene circuitry within individual cells while preserving spatial context. This innovation, created at the...