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New Spatial Gene Editing Method Unveiled: Perturb-FISH Advances Genetic Research

Key Points Perturb-FISH enhances gene circuitry analysis by preserving spatial relationships between cells. Developed at the Broad Institute, it combines CRISPR screening with spatial transcriptomics. The method revealed the effects of autism-related genes on brain cells and tumor-immune interactions. The technology can analyze 35 genes but aims to expand its capabilities further. Scientists have developed a cutting-edge technology called Perturb-FISH that enhances the ability to study gene circuitry within individual cells while preserving spatial context. This innovation, created at the...

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Los Alamos Study Reveals Cosmic-Ray Showers Trigger Lightning Flashes

Key Points Los Alamos researchers discovered that cosmic-ray showers help trigger lightning by creating ionized pathways in clouds. The team used BIMAP-3D, an advanced 3D mapping system, to monitor lightning discharges. They observed a slanted polarization pattern in lightning discharges, deviating from the storm’s electric field. The Earth’s magnetic field deflects high-energy electrons and positrons from cosmic rays, affecting the discharge direction. Researchers at Los...

3D Printing Advances Large-Scale Particle Detectors for Neutrino Research

Key Points Researchers developed a 3D-printed plastic scintillator detector for particle physics. The T2K experiment’s SuperFGD detector consists of two million plastic cubes. 3D printing offers a faster, cost-effective alternative to traditional assembly methods. The new FIM technique improves manufacturing by combining FDM and injection molding. The 125-voxel SuperCube performed comparably to conventional detectors in cosmic particle tests. An international research team led by experts...

Scientists Extend Lyddane-Sachs-Teller Relation to Magnetism, Unlocking New Possibilities in Material Science

Key Points Scientists at Lund University extended the Lyddane-Sachs-Teller relation to magnetism, introducing the Magnetic LST relation. The MLST relation connects a material’s static permeability to its magnetic resonance frequencies. Researchers validated their findings using a novel optical technique (THz-EPR-GSE) and SQUID magnetometry. To confirm the new relation, the study focused on an iron-doped gallium nitride (GaN) semiconductor. Researchers at Lund University have made a...