Key Points A novel two-stage carboplatin delivery system inhibits tumor growth and enhances radiotherapy. Hydrogel releases carboplatin early, while carboplatin particles target cancer cells later. Preclinical trials showed tumor eradication in mice with minimal radiation doses. The study demonstrates the potential for clinical impact and multidisciplinary innovation in glioma treatment. Malignant gliomas, particularly glioblastoma and anaplastic astrocytoma, represent over 70% of adult primary brain cancers. Despite aggressive treatments like tumor excision and concurrent chemoradiotherapy, local recurrence remains a significant challenge,...